/* ============================================================
   SNV-MWAS catalog — shared design system
   ============================================================ */
:root{
  --brand:#0369a1;      /* sky 700 — aligned with PanGWAS-IBD */
  --brand-2:#075985;    /* sky 800 */
  --brand-3:#0c4a6e;    /* sky 900 */
  --brand-soft:#e0f2fe; /* sky 100 */
  --accent:#ea580c;     /* orange CTA */
  --cyan:#0284c7;       /* sky accent */
  --sig:#059669;        /* significance / success */
  --missense:#dc2626;
  --synonym:#0369a1;
  --noncoding:#7c3aed;
  --ink:#0f172a;
  --ink-2:#334155;
  --muted:#64748b;
  --line:#e8edf3;
  --bg:#f4f7fb;
  --card:#ffffff;
  --radius:16px;
  --shadow:0 1px 2px rgba(15,23,42,.03), 0 6px 20px rgba(15,23,42,.05);
  --shadow-lg:0 16px 48px rgba(3,105,161,.14);
  --font:'Source Sans 3','Segoe UI',Roboto,sans-serif;
  --mono:'IBM Plex Mono','SFMono-Regular',ui-monospace,Menlo,Consolas,monospace;
}
*{box-sizing:border-box}
html{scroll-behavior:smooth}
body{
  font-family:var(--font);
  color:var(--ink);
  background:var(--bg);
  margin:0;
  line-height:1.6;
  -webkit-font-smoothing:antialiased;
}
a{color:var(--brand);text-decoration:none}
a:hover{text-decoration:underline}
h1,h2,h3,h4{color:var(--ink);font-weight:700;letter-spacing:-.02em;line-height:1.2}
.container{max-width:1200px;margin:0 auto;padding:0 22px}
.mono{font-family:var(--mono)}
.muted{color:var(--muted)}

/* ---------- top nav ---------- */
.nav{
  position:sticky;top:0;z-index:1000;
  background:rgba(255,255,255,.9);
  backdrop-filter:saturate(180%) blur(12px);
  border-bottom:1px solid var(--line);
}
.nav-inner{display:flex;align-items:center;gap:8px;height:62px;max-width:1200px;margin:0 auto;padding:0 22px}
.brand{display:flex;align-items:center;gap:11px;font-weight:800;font-size:1.16rem;color:var(--ink);letter-spacing:-.03em}
.brand:hover{text-decoration:none}
.brand .logo{
  width:34px;height:34px;border-radius:9px;flex:none;
  background:linear-gradient(135deg,var(--brand),var(--accent));
  display:grid;place-items:center;color:#fff;font-size:17px;
  box-shadow:0 4px 12px rgba(3,105,161,.35);
}
.brand small{display:block;font-weight:500;font-size:.62rem;letter-spacing:.14em;color:var(--muted);text-transform:uppercase;margin-top:-2px}
.nav-links{display:flex;gap:2px;margin-left:auto;align-items:center}
.nav-links a{
  color:var(--ink-2);font-weight:600;font-size:.92rem;padding:8px 14px;border-radius:9px;transition:.15s;
}
.nav-links a:hover{background:var(--brand-soft);color:var(--brand-2);text-decoration:none}
.nav-links a.active{background:var(--brand);color:#fff}
.nav-toggle{display:none;margin-left:auto;background:none;border:0;font-size:1.4rem;color:var(--ink);cursor:pointer}
@media(max-width:860px){
  .nav-links{display:none;position:absolute;top:62px;left:0;right:0;flex-direction:column;background:#fff;border-bottom:1px solid var(--line);padding:10px 16px;gap:4px}
  .nav-links.open{display:flex}
  .nav-toggle{display:block}
}

/* ---------- hero ---------- */
.hero{
  position:relative;overflow:hidden;color:#fff;
  background:radial-gradient(1100px 560px at 85% -15%,#38bdf8 0%,transparent 55%),
             radial-gradient(900px 480px at 8% 110%,rgba(234,88,12,.35) 0%,transparent 50%),
             linear-gradient(120deg,#0c4a6e 0%,#0369a1 55%,#0e7490 100%);
}
.hero::after{content:"";position:absolute;inset:0;
  background-image:radial-gradient(rgba(255,255,255,.08) 1px,transparent 1px);
  background-size:24px 24px;opacity:.5;pointer-events:none}
.hero-inner{position:relative;z-index:2;padding:76px 0 62px}
.hero h1{color:#fff;font-size:2.75rem;margin:0 0 16px;font-weight:800;line-height:1.12}
.hero .tag{display:inline-flex;align-items:center;gap:8px;background:rgba(255,255,255,.16);border:1px solid rgba(255,255,255,.28);
  padding:6px 15px;border-radius:30px;font-size:.82rem;font-weight:600;margin-bottom:22px;backdrop-filter:blur(4px)}
.hero p.lead{font-size:1.12rem;color:#e0f2fe;max-width:730px;margin:0 0 28px;line-height:1.65}
.hero .cta{display:flex;gap:12px;flex-wrap:wrap}
.hero-figure{
  position:absolute;
  right:clamp(-5rem,-2vw,0rem);
  top:-36%;
  bottom:auto;
  transform:translateY(0);
  z-index:1;
  pointer-events:none;
  perspective:900px;
  perspective-origin:35% 100%;
  width:clamp(360px,48vw,860px);
}
.hero-figure__stage{
  --spin:42deg;
  /* Lower eye height → stronger foreshortening (higher rotateX) */
  position:relative;
  transform:rotateX(66deg) rotateZ(var(--spin)) scale(1.18);
  transform-origin:32% 100%;
  transform-style:preserve-3d;
  animation:heroFloat 8s ease-in-out infinite;
  /* Fade out toward FAR (upper side of the page after rotation) */
  -webkit-mask-image:linear-gradient(calc(0deg - var(--spin)), #000 0%, #000 48%, rgba(0,0,0,.55) 72%, transparent 100%);
  mask-image:linear-gradient(calc(0deg - var(--spin)), #000 0%, #000 48%, rgba(0,0,0,.55) 72%, transparent 100%);
}
.hero-figure__paper{
  position:relative;
  background:#fff;
  border-radius:5px;
  padding:9px 11px;
  box-shadow:
    0 2px 4px rgba(15,23,42,.05),
    0 16px 36px rgba(15,23,42,.2),
    0 40px 70px rgba(15,23,42,.16);
}
.hero-figure__stack{
  position:relative;
  display:block;
  line-height:0;
  overflow:hidden;
  border-radius:2px;
}
.hero-figure__img{
  display:block;width:100%;height:auto;
  backface-visibility:hidden;
}
.hero-figure__img--sharp{
  position:relative;z-index:1;
  opacity:1;filter:none;
}
.hero-figure__img--mid,
.hero-figure__img--far{
  position:absolute;left:0;top:0;width:100%;height:100%;
  object-fit:fill;
  pointer-events:none;
}
/* Near (page-bottom / toward viewer) clear → far (page-top) soft */
.hero-figure__img--mid{
  z-index:2;
  filter:blur(2.8px);
  -webkit-mask-image:linear-gradient(calc(0deg - var(--spin)), transparent 0%, transparent 45%, rgba(0,0,0,.55) 70%, #000 100%);
  mask-image:linear-gradient(calc(0deg - var(--spin)), transparent 0%, transparent 45%, rgba(0,0,0,.55) 70%, #000 100%);
}
.hero-figure__img--far{
  z-index:3;
  filter:blur(12px);
  -webkit-mask-image:linear-gradient(calc(0deg - var(--spin)), transparent 0%, transparent 58%, rgba(0,0,0,.4) 78%, #000 100%);
  mask-image:linear-gradient(calc(0deg - var(--spin)), transparent 0%, transparent 58%, rgba(0,0,0,.4) 78%, #000 100%);
}
@keyframes heroFloat{
  0%,100%{transform:rotateX(66deg) rotateZ(var(--spin)) scale(1.18) translateY(0)}
  50%{transform:rotateX(66deg) rotateZ(var(--spin)) scale(1.18) translateY(-4px)}
}
@media(max-width:1100px){
  .hero-figure{width:clamp(320px,44vw,640px);top:-28%}
}
@media(max-width:900px){.hero-figure{display:none}}
@media(max-width:640px){.hero h1{font-size:2rem}}

/* page header (inner pages) */
.page-hero{position:relative;overflow:hidden;color:#fff;
  background:linear-gradient(120deg,#0c4a6e 0%,#0369a1 60%,#0e7490 100%);padding:42px 0 36px}
.page-hero h1{color:#fff;font-size:2rem;margin:0 0 8px}
.page-hero p{color:#dbeafe;margin:0;max-width:720px}

/* ---------- buttons ---------- */
.btn{display:inline-flex;align-items:center;gap:9px;font-weight:600;font-size:.94rem;
  padding:11px 20px;border-radius:11px;border:1px solid transparent;cursor:pointer;transition:.15s;text-decoration:none}
.btn:hover{text-decoration:none;transform:translateY(-1px)}
.btn-primary{background:var(--accent);color:#3a2600;box-shadow:0 4px 12px rgba(245,158,11,.28)}
.btn-primary:hover{background:#fbbf24;color:#3a2600;box-shadow:0 6px 16px rgba(245,158,11,.34)}
.btn-light{background:rgba(255,255,255,.14);color:#fff;border-color:rgba(255,255,255,.32)}
.btn-light:hover{background:rgba(255,255,255,.24);color:#fff}
.btn-outline{background:#fff;color:var(--brand);border-color:var(--line)}
.btn-outline:hover{border-color:var(--brand);background:var(--brand-soft)}
.btn-brand{background:var(--brand);color:#fff}
.btn-brand:hover{background:var(--brand-2);color:#fff}
.btn-sm{padding:7px 13px;font-size:.85rem;border-radius:9px}

/* ---------- KPI stat row ---------- */
.kpi-row{display:grid;grid-template-columns:repeat(6,1fr);gap:14px;position:relative;z-index:1}
.kpi-row.kpi-row-5{grid-template-columns:repeat(5,1fr);margin-top:8px}
@media(max-width:980px){.kpi-row,.kpi-row.kpi-row-5{grid-template-columns:repeat(3,1fr)}}
@media(max-width:560px){.kpi-row,.kpi-row.kpi-row-5{grid-template-columns:repeat(2,1fr)}}
.kpi{background:var(--card);border:1px solid var(--line);border-radius:14px;padding:18px 16px;box-shadow:var(--shadow);text-align:left;transition:transform .2s ease, box-shadow .2s ease}
.kpi:hover{transform:translateY(-3px);box-shadow:var(--shadow-lg)}
.kpi .num{font-size:1.72rem;font-weight:800;letter-spacing:-.03em;line-height:1;
  font-variant-numeric:tabular-nums;
  background:linear-gradient(135deg,var(--brand),var(--cyan));-webkit-background-clip:text;background-clip:text;-webkit-text-fill-color:transparent;color:var(--brand)}
.kpi .lbl{font-size:.76rem;color:var(--muted);font-weight:600;margin-top:7px;text-transform:uppercase;letter-spacing:.04em}
.kpi .ic{float:right;color:var(--brand-soft);font-size:1.2rem}
.chip.removable{display:inline-flex;align-items:center;gap:8px;padding-right:6px}
.chip .chip-x{
  display:inline-grid;place-items:center;width:20px;height:20px;border-radius:50%;
  border:0;background:rgba(3,105,161,.12);color:var(--brand-2);cursor:pointer;font-size:.7rem;line-height:1;padding:0;
}
.chip .chip-x:hover{background:var(--brand);color:#fff}

/* ---------- generic card / section ---------- */
section.block{padding:52px 0}
.section-head{display:flex;align-items:flex-end;justify-content:space-between;gap:16px;margin-bottom:28px;flex-wrap:wrap}
.section-head h2{font-size:1.6rem;margin:0;letter-spacing:-.02em}
.section-head .sub{color:var(--muted);font-size:.95rem;margin-top:6px;line-height:1.45;max-width:720px;position:relative;z-index:2}
.eyebrow{text-transform:uppercase;letter-spacing:.12em;font-size:.72rem;font-weight:700;color:var(--brand);margin-bottom:6px}
.card{background:var(--card);border:1px solid var(--line);border-radius:var(--radius);box-shadow:var(--shadow);padding:22px;transition:box-shadow .2s ease}
.card:hover{box-shadow:0 4px 14px rgba(15,23,42,.06), 0 18px 44px rgba(15,23,42,.07)}
.card h3{font-size:1.06rem;margin:0 0 4px}
.card .card-sub{color:var(--muted);font-size:.86rem;margin-bottom:14px}
.grid{display:grid;gap:18px}
.g-2{grid-template-columns:repeat(2,1fr)}
.g-3{grid-template-columns:repeat(3,1fr)}
.g-2-1{grid-template-columns:2fr 1fr}
.g-1-2{grid-template-columns:1fr 2fr}
@media(max-width:900px){.g-2,.g-3,.g-2-1,.g-1-2{grid-template-columns:1fr}}

.chart{width:100%;height:340px}
.chart.tall{height:420px}
.chart.short{height:260px}

.chips{display:flex;flex-wrap:wrap;gap:8px;margin-top:8px}
.chip{display:inline-flex;align-items:center;gap:7px;font-size:.8rem;font-weight:600;color:var(--ink-2);
  background:#f1f5f9;border:1px solid var(--line);padding:5px 11px;border-radius:20px;cursor:pointer;transition:.12s}
.chip:hover,.chip.active{border-color:var(--brand);color:var(--brand);background:var(--brand-soft)}
.chip .dot{width:9px;height:9px;border-radius:50%;flex:none}

/* highlight / feature cards */
.feat{display:grid;grid-template-columns:repeat(3,1fr);gap:14px}
@media(max-width:820px){.feat{grid-template-columns:1fr}}
.hi-grid{display:grid;grid-template-columns:repeat(4,1fr);gap:14px}
@media(max-width:900px){.hi-grid{grid-template-columns:repeat(2,1fr)}}
@media(max-width:560px){.hi-grid{grid-template-columns:1fr}}
.feat .f-card{border-radius:14px;padding:22px;border:1px solid var(--line);background:var(--card);box-shadow:var(--shadow)}
.feat .f-card .icon{
  width:48px;height:48px;border-radius:12px;display:grid;place-items:center;color:#fff;margin-bottom:14px;
  background:linear-gradient(135deg,var(--brand),var(--cyan));
}
.feat .f-card h3{margin:0 0 8px;font-size:1.05rem}
.feat .f-card p{margin:0;color:var(--muted);font-size:.92rem}

/* download cards */
.dl-grid{display:grid;grid-template-columns:repeat(2,1fr);gap:16px}
@media(max-width:800px){.dl-grid{grid-template-columns:1fr}}
.dl-card{display:flex;gap:16px;align-items:flex-start;padding:20px;border:1px solid var(--line);border-radius:14px;background:#fff;box-shadow:var(--shadow)}
.dl-card .ico{
  width:52px;height:52px;border-radius:12px;flex:none;display:grid;place-items:center;color:#fff;font-size:1.3rem;
  background:linear-gradient(135deg,var(--brand),var(--cyan));
}
.dl-card h3{margin:0 0 4px;font-size:1.05rem}
.dl-card p{margin:0 0 10px;color:var(--muted);font-size:.9rem}
.dl-meta{font-size:.8rem;color:var(--muted)}

/* tables */
table.tbl{width:100%;border-collapse:collapse;font-size:.9rem}
table.tbl th,table.tbl td{text-align:left;padding:9px 12px;border-bottom:1px solid var(--line)}
table.tbl th{color:var(--muted);font-weight:600;font-size:.78rem;text-transform:uppercase;letter-spacing:.03em;background:#fafbfc}
table.tbl tr:hover td{background:#f8fafc}

/* badges */
.badge{display:inline-block;padding:2px 9px;border-radius:20px;font-size:.74rem;font-weight:700;line-height:1.5}
.b-sig{background:#d1fae5;color:#047857}
.b-ns{background:#f1f5f9;color:#475569}
.b-missense{background:#fee2e2;color:#991b1b}
.b-synonym{background:#dbeafe;color:#1e40af}
.b-noncoding{background:#ede9fe;color:#5b21b6}
.b-meta{background:#cffafe;color:#0e7490}
.b-dmp{background:#e0e7ff;color:#3730a3}
.b-grey{background:#f1f5f9;color:#475569}

/* footer */
footer.ft{background:linear-gradient(135deg,var(--brand-3),#0c1a33);color:#bfdbfe;padding:44px 0 30px;margin-top:56px}
footer.ft a{color:#fff}
footer.ft .cols{display:grid;grid-template-columns:2fr 1fr 1fr;gap:30px}
@media(max-width:760px){footer.ft .cols{grid-template-columns:1fr}}
footer.ft h4{color:#fff;font-size:.82rem;text-transform:uppercase;letter-spacing:.08em;margin:0 0 12px}
footer.ft ul{list-style:none;padding:0;margin:0}
footer.ft li{margin-bottom:8px;font-size:.9rem}
footer.ft .fbrand{font-size:1.3rem;font-weight:800;color:#fff;margin-bottom:8px}
footer.ft .copy{border-top:1px solid rgba(255,255,255,.15);margin-top:26px;padding-top:18px;font-size:.82rem;color:#93c5fd;display:flex;justify-content:space-between;flex-wrap:wrap;gap:8px}
footer.ft .ack{margin-top:12px;max-width:420px;opacity:.9}
footer.ft .lab-logo{height:52px;background:#fff;padding:4px 8px;border-radius:6px}

.callout{border-left:4px solid var(--brand);background:var(--brand-soft);padding:14px 18px;border-radius:0 12px 12px 0;font-size:.92rem;color:var(--brand-2)}
.callout.warn{border-color:var(--accent);background:#fffbeb;color:#92400e}

/* forms / filters */
.field{display:flex;flex-direction:column;gap:5px}
.field label{font-size:.78rem;font-weight:700;color:var(--ink-2);text-transform:uppercase;letter-spacing:.03em}
.field select,.field input,textarea.inp,.inp{
  font-family:var(--font);font-size:.92rem;padding:9px 12px;border:1px solid var(--line);border-radius:10px;background:#fff;color:var(--ink);width:100%}
.field select:focus,.inp:focus,textarea.inp:focus{outline:none;border-color:var(--brand);box-shadow:0 0 0 3px var(--brand-soft)}

.search-wrap{position:relative}
.suggest{
  position:absolute;left:0;right:0;top:calc(100% + 6px);z-index:50;
  background:#fff;border:1px solid var(--line);border-radius:12px;box-shadow:var(--shadow-lg);
  max-height:280px;overflow:auto;display:none
}
.suggest.open{display:block}
.suggest button{
  display:flex;width:100%;text-align:left;gap:10px;align-items:center;
  border:0;background:none;padding:10px 14px;cursor:pointer;font:inherit;color:var(--ink)
}
.suggest button:hover,.suggest button.active{background:var(--brand-soft)}
.suggest .kind{font-size:.7rem;font-weight:700;text-transform:uppercase;letter-spacing:.04em;color:var(--muted);min-width:72px}

.spinner{width:34px;height:34px;border:3px solid var(--line);border-top-color:var(--brand);border-radius:50%;animation:spin .8s linear infinite;margin:26px auto}
@keyframes spin{to{transform:rotate(360deg)}}

.pills{display:inline-flex;background:#eef2f7;border-radius:12px;padding:4px;gap:4px}
.pills button{border:0;background:none;padding:8px 16px;border-radius:9px;font-weight:600;font-size:.88rem;color:var(--muted);cursor:pointer}
.pills button.active{background:#fff;color:var(--brand);box-shadow:var(--shadow)}

/* DataTables theme overrides */
.dataTables_wrapper .dataTables_paginate .paginate_button.current,
.dataTables_wrapper .dataTables_paginate .paginate_button.current:hover{
  background:var(--brand)!important;border-color:var(--brand)!important;color:#fff!important
}
.dataTables_wrapper .dataTables_paginate .paginate_button:hover{
  background:var(--brand-soft)!important;border-color:var(--brand)!important;color:var(--brand-2)!important
}
table.dataTable thead th{background:#f8fafc;border-bottom:2px solid var(--line)!important;font-size:.78rem;text-transform:uppercase;letter-spacing:.03em;color:var(--muted)}
table.dataTable tbody tr:hover{background:rgba(37,99,235,.04)}

/* browse layout */
.browse-layout{display:grid;grid-template-columns:280px 1fr;gap:18px;align-items:start}
@media(max-width:980px){.browse-layout{grid-template-columns:1fr}}
.filter-panel{position:sticky;top:78px;background:#fff;border:1px solid var(--line);border-radius:var(--radius);padding:18px;box-shadow:var(--shadow)}
.filter-panel .field{margin-bottom:12px}
.filter-actions{display:flex;gap:8px;flex-wrap:wrap;margin-top:8px}

.sum-cards{display:grid;grid-template-columns:repeat(4,1fr);gap:12px;margin-bottom:18px}
@media(max-width:800px){.sum-cards{grid-template-columns:repeat(2,1fr)}}
.sum-card{background:#fff;border:1px solid var(--line);border-radius:12px;padding:14px 16px}
.sum-card .n{font-size:1.4rem;font-weight:800;color:var(--brand)}
.sum-card .l{font-size:.78rem;color:var(--muted);font-weight:600;text-transform:uppercase;letter-spacing:.04em}

/* about */
.prose{max-width:820px}
.prose h2{font-size:1.35rem;margin:34px 0 10px}
.prose h3{font-size:1.05rem;margin:22px 0 6px}
.prose p,.prose li{color:var(--ink-2);font-size:.98rem}
.prose li{margin-bottom:6px}
.toc{position:sticky;top:80px}
.toc a{display:block;padding:6px 12px;border-left:2px solid var(--line);color:var(--muted);font-size:.9rem;font-weight:600}
.toc a:hover{color:var(--brand);border-color:var(--brand);text-decoration:none}
.about-layout{display:grid;grid-template-columns:1fr 220px;gap:34px;align-items:start}
@media(max-width:900px){.about-layout{grid-template-columns:1fr}.toc{display:none}}
.steps{counter-reset:s;list-style:none;padding:0}
.steps li{position:relative;padding-left:44px;margin-bottom:14px;color:var(--ink-2)}
.steps li::before{counter-increment:s;content:counter(s);position:absolute;left:0;top:-2px;width:30px;height:30px;border-radius:50%;background:var(--brand-soft);color:var(--brand-2);font-weight:800;display:grid;place-items:center}

/* homepage feature cards */
.feat-grid{display:grid;grid-template-columns:repeat(3,1fr);gap:18px}
@media(max-width:900px){.feat-grid{grid-template-columns:1fr}}
.feat-card{
  position:relative;overflow:hidden;
  background:var(--card);border:1px solid var(--line);border-radius:var(--radius);
  padding:26px 24px 22px;box-shadow:var(--shadow);text-decoration:none;color:inherit;
  transition:transform .2s ease, box-shadow .2s ease, border-color .2s ease;
}
.feat-card:hover{
  transform:translateY(-4px);text-decoration:none;color:inherit;
  border-color:rgba(3,105,161,.28);
  box-shadow:var(--shadow-lg);
}
.feat-card::before{
  content:"";position:absolute;left:0;top:0;bottom:0;width:4px;
  background:linear-gradient(180deg,var(--brand),var(--accent));
}
.feat-card .icon{
  width:52px;height:52px;border-radius:14px;display:grid;place-items:center;
  color:#fff;font-size:1.25rem;margin-bottom:16px;
  background:linear-gradient(135deg,var(--brand),var(--cyan));
  box-shadow:0 8px 18px rgba(3,105,161,.22);
}
.feat-card.accent-orange .icon{background:linear-gradient(135deg,#c2410c,var(--accent));box-shadow:0 8px 18px rgba(234,88,12,.22)}
.feat-card.accent-teal .icon{background:linear-gradient(135deg,#0f766e,#14b8a6);box-shadow:0 8px 18px rgba(20,184,166,.22)}
.feat-card h3{margin:0 0 8px;font-size:1.12rem;color:var(--ink)}
.feat-card p{margin:0;color:var(--muted);font-size:.95rem;line-height:1.55}
.feat-card .more{
  display:inline-flex;align-items:center;gap:6px;margin-top:14px;
  font-size:.85rem;font-weight:700;color:var(--brand);
}
.feat-card:hover .more{gap:10px}
.hi-grid .c-card .hi-num{
  font-size:1.9rem;font-weight:800;line-height:1;
  font-variant-numeric:tabular-nums;
}