Single Nucleotide Variant-based Metagenome-Wide Association Study
Comprehensive database of gut microbial SNV associations with human phenotypes and environmental factors
Comprehensive database of gut microbial SNV associations with human phenotypes and environmental factors
The first phenome-scale gut microbial SNV-MWAS
Advancing genetic and functional exploration of gut microbial strains
Exploring associations between gut microbial SNVs and host health and environmental exposures through an interactive database interface
Mechanistic hypotheses for microbial functionality in human health with detailed functional annotation
Fully downloadable database and reference resources for customized exploration and re-mining
Gut microbes contain millions of single nucleotide variants (SNVs), and their association with environmental exposome and human health is under-explored.
By focusing on core-genome common SNVs in the gut microbiome, we identified 49,346 study-wide significant associations (Pmeta-analysis < 5.42 × 10⁻¹¹) through meta-analysis, linking 39,663 SNVs from 101 gut microbial species to 69 human phenotypes and exposure factors. These findings provide strain-level mechanistic hypotheses regarding microbial functionality in human health. Full details are available in our preprint at Research Square.
Research Square