Group members

Projects

Tool development

Drag and Drop

Our mission

To develop innovative experimental and bioinformatic frameworks for understanding host-microbe interactions in human health and disease.

A few things that we are going on

The research group has two key biological and two technological components, which are well linked between each other to support the overall mission of the group

The human genome


to identify genetic risk factors that contribute to disease
susceptibility, progression and response to retreatment.

The Gut microbiome


to identify which reside in the human gut and how their
interactions with host’s genome and environment contribute to human health

Big data


our research leaveages large-scale, multidimentional omics data and cutting-edge bioinformatic tools

Biotechnology


our research engages state-of-art biotechnologies, such as organ-on-a-chip and molecular technologies, for molecular biology studies.

Publications

Title Year Cited by
HLA-II peptide-binding diversity shapes humoral immune responses and susceptibility to infections
B Magyari, AT Fülöp, D Kókai, F Tóth, GM Balogh, S Andreu-Sánchez, …
Nature Communications, 2026
2026 0
Evaluation of the immortalized primary human hepatocyte cell line Fa2N-4 as a model for MASLD
VEJM Palasantzas, D Struik, T Bos, MH Koster, J Gelderloos, ER Vos, …
Gastro Hep Advances, 101069, 2026
2026 0
Compositional microbiome-based signatures associate with general health status: findings from a large population-based cohort study
M Pujolassos, A Kurilshikov, RK Weersma, J Fu, A Zhernakova, ML Calle
medRxiv, 2026.06. 03.26354796, 2026
2026 0
Multi-cohort proteogenomic analyses reveal genetic effects across the proteome and diseasome
M Koprulu, K Smith-Byrne, BR Ferolito, E Macdonald-Dunlop, J Luan, …
Cell 189 (11), 3339-3357. e11, 2026
2026 2
Genetics meets the gut mycobiome
D Wang, V Kumar, J Fu
Vita, 2026
2026 0
Pregnancy and Early-Life Gut Virome in the Lifelines NEXT cohort: Origin, Persistence, Influencing Factors and Health Implications
A Fernández-Pato, A Gulyaeva, N Kuzub, T Sinha, S Brushett, …
bioRxiv, 2026.03. 05.709809, 2026
2026 0
The interplay of sleep characteristics with health factors and gut microbiome
J Wu, S Andreu-Sánchez, H Peng, R Gacesa, MB Gois, S Brushett, …
Nature Communications 17 (1), 2731, 2026
2026 7
Embracing the Dragon‐Horse Spirit: Gratitude and forward momentum
YX Liu, Y Gao, T Chen, D Li, C Lan, CL Shi, J Fu, SJ Liu
iMeta 5 (1), e70110, 2026
2026 0
Assessing Nutraceuticals for Hepatic Steatosis: A Standardized In Vitro Approach
VEJM Palasantzas, D Struik, T Bos, S Withoff, J Fu, JW Jonker, …
Nutrients 18 (3), 388, 2026
2026 2
Comparison of hiPSC-derived hepatic organoids and liver-on-a-chip systems reveal microenvironment-driven maturation
I Tamargo Rubio, T Krempel, VEJM Palasantzas, B Green, GDL Weijer, …
bioRxiv, 2026.07. 28.741157, 2026
2026 0
Comprehensive profiling of infant gut virome assembly reveals associations with eczema and wheeze
S Garmaeva, N Kuzub, A Fernández-Pato, S Sheveleva, …
bioRxiv, 2026.06. 24.734081, 2026
2026 0
DNA methylation of genes involved in lipid metabolism drives adiponectin levels and metabolic disease
L Sinke, T Delerue, R Wilson, X Lu, Y Xia, R Costeira, MK Nasr, …
Diabetologia 69 (1), 127-145, 2026
2026 8
New insights in amino sugar metabolism by the gut microbiome
W Shen, JF de Boer, F Kuipers, J Fu
Gut Microbes 17 (1), 2510462, 2025
2025 11
High-resolution analysis of the treated coeliac disease microbiome reveals strain-level variation
J Slager, HL Simpson, R Gacesa, L Chen, IL Tan, J Gelderloos, …
Gut microbes 17 (1), 2489071, 2025
2025 3
Multi-dimensional metagenomics
H Peng, AJ Ruiz-Moreno, J Fu
Nature Reviews Bioengineering 3 (12), 1057-1072, 2025
2025 17
Crohn’s disease and ulcerative colitis exhibit prediagnostic antibody signatures with shared and divergent changes towards disease onset
AR Bourgonje, S Andreu-Sánchez, R Gacesa, G Innocenti, IN Kalka, …
Gut 74 (12), 1977-1988, 2025
2025 9
Longitudinal gut microbiota tracking reveals the dynamics of horizontal gene transfer
H Peng, S Andreu-Sanchez, AJ Ruiz-Moreno, A Fernández-Pato, J Wu, …
Nature Communications 16 (1), 11543, 2025
2025 17
Misfortunes never come singly: Microbial metabolites link heart failure and chronic kidney disease
J Fu, NVAM Knoers
Cell Host & Microbe 33 (10), 1652-1654, 2025
2025 1
iMeta: Boosting academic sharing and collaboration via social media
X Yao, J Wu, T Ma, CL Shi, C Lan, D Li, J Fu, Z Shen, T Chen, YX Liu
Imeta 4 (5), e70085, 2025
2025 1
Distinct microbial and metabolic shifts characterize acute coronary syndrome and recovery
J Xu, D Dai, Y Yang, S Gao, J Yang, C Dong, W Yang, J Yuan, T Wang, …
Imeta 4 (5), e70079, 2025
2025 5