Phenome-scale gut microbial SNV-MWAS

Single Nucleotide Variant-based Metagenome-Wide Association Study

Comprehensive database of gut microbial SNV associations with human phenotypes and environmental factors

Explore associations Preprint
Study design

Source of Study

The first phenome-scale gut microbial SNV-MWAS.
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Cohorts
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Host individuals
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Phenotypes
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Gut microbial species
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Microbial SNVs
Meta-analysis highlights

Study-wide significant discoveries

Pmeta < 5.42×10⁻¹¹ linking microbial SNVs to host traits and exposures.

Catalog by study

Association rows from DMP vs meta-analysis.

SNV consequence

Predicted variant effect on coding sequence.

Study-wide significance

Rows meeting the catalog significance flag.

Top phenotypes

Click a bar to open Explore with that phenotype filter.

Top species

Click a bar to browse associations for that taxon.

Phylum composition

Catalog rows by GTDB phylum of the species carrying the SNV.

Quick search

Jump straight to phenotype, species or SNV ID.
Age BMI Eosinophils 102274_1617247
Capabilities

Database features

What this catalog helps you do.

SNV-level associations

Strain-resolved links between gut microbial variants and host health or environmental exposures.

Open Explore

Functional annotation

Gene products, UniRef clusters, Pfam domains and predicted SNV consequences for mechanistic hypotheses.

Read methods

Open access

Fully downloadable association catalog and UHGG reference resources for offline re-mining.

Go to downloads

Ready to dig into the associations?

Open Explore to query a phenotype or species, or jump straight to meta-analysis study-wide hits.

Explore Significant hits